Depends a bit on the specific set, but broadly speaking: yes, for normal play. Even well-made dice can have tiny inconsistencies in shape, polish, and weight. In practice, those differences are usually trivial compared to the chaos of an actual roll. And for RPG dice specifically, the numbers are intentionally scattered so any small “preference” is less likely to matter. Our rule of thumb: if you’re doing high-stakes scientific research, don’t use gaming dice. For board games, TTRPGs, and everyday rolling, they’re great.